Hemophilia A in nagpur, also known as classic hemophilia, is one of three types of hemophilia. This rare blood disorder occurs when the blood doesn’t clot properly due to a deficiency in a specific blood protein called a clotting factor. Hemophilia A predominantly affects men and individuals assigned male at birth (AMAB), but it can also affect women and individuals assigned female at birth (AFAB).
Current treatments involve replacing the missing clotting factor. Additionally, healthcare providers are exploring gene therapy and gene replacement therapy as potential new treatments for Hemophilia A and other forms of hemophilia.
The severity of symptoms can vary. Prolonged bleeding is the primary symptom and is often first noticed during an infant’s circumcision. Other bleeding issues typically emerge when the infant begins crawling and walking.Mild cases may go unnoticed until later in life, with symptoms potentially first appearing after surgery or injury. Internal bleeding can occur anywhere in the body.
Symptoms can include:
Treatment involves replacing the missing clotting factor, typically with factor VIII concentrates. The dosage depends on:
Mild hemophilia may be treated with desmopressin (DDAVP), a medication that helps release stored factor VIII from the lining of blood vessels.
To prevent bleeding crises, individuals with hemophilia and their families can learn to administer factor VIII concentrates at home at the first signs of bleeding. Those with severe forms of hemophilia may require regular preventive treatment.
DDAVP or factor VIII concentrate may also be necessary before dental extractions or surgery.
It’s recommended to get the hepatitis B vaccine, as people with hemophilia are at higher risk of contracting hepatitis B due to receiving blood products.
Some individuals with hemophilia A develop antibodies against factor VIII, known as inhibitors, which neutralize the effectiveness of factor VIII. In such cases, a synthetic clotting factor called VIIa can be administered.
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